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ea0014p13 | (1) | ECE2007

Rosiglitazone interferes with the inflammatory response induced in human endothelial cells by TNFalpha and IFNgamma through a new mechanism involving extracellular signal-regulated kinases (ERKs)

Lombardi Adriana , Piscitelli Elisabetta , Francalanci Michela , Mello Tommaso , Santarlasci Veronica , Gelmini Stefania , Cantini Giulia , Galli Andrea , Cosmi Lorenzo , Annunziato Francesco , Forti Gianni , Serio Mario , Luconi Michaela

Microvascular endothelium is one of the main character and target involved in the inflammatory response. Upon specific activation, endothelial cells massively recruit Th1 IFNgamma secreting lymphocytes at the inflammatory site. In the present study, we investigate the intracellular signalling mediating TNFalpha (T) and IFNgamma (I) inflammatory response in a human endothelial cell line (HMEC-1) in vitro and the interfering effects of rosiglitazone (RGZ), a peroxisome pr...

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Rosiglitazone interferes with the inflammatory response induced in human endothelial cells by TNFalpha and IFNgamma through a new mechanism involving extracellular signal-regulated kinases (ERKs)

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